CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.160.20
Functional Family double-stranded RNA-specific editase 1 isoform X1

Enzyme Information

3.5.4.37
Double-stranded RNA adenine deaminase.
based on mapping to UniProt Q91ZS8
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

Q91ZS8
RED1_MOUSE
Mus musculus
Double-stranded RNA-specific editase 1

PDB Structure

PDB 2L2K
External Links
Method SOLUTION NMR
Organism
Primary Citation
The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove.
Stefl, R., Oberstrass, F.C., Hood, J.L., Jourdan, M., Zimmermann, M., Skrisovska, L., Maris, C., Peng, L., Hofr, C., Emeson, R.B., Allain, F.H.
Cell(Cambridge,Mass.)