CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.8 | Helicase, Ruva Protein; domain 3 |
|
1.10.8.800 | D-family DNA polymerase, DP1 subunit N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | D-family DNA polymerase, DP1 subunit N-terminal domain |
| Functional Family |
Enzyme Information
| 3.1.11.1 |
Exodeoxyribonuclease I.
based on mapping to UniProt O57863
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt O57863
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| O57863 |
DP2S_PYRHO
Pyrococcus horikoshii OT3
DNA polymerase II small subunit
|
PDB Structure
| PDB | 2KXE |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the N-terminal domain of the archaeal D-family DNA polymerase small subunit reveals evolutionary relationship to eukaryotic B-family polymerases
Febs Lett.
|
