CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family Copper-transporting ATPase 1, putative

Enzyme Information

7.2.2.8
P-type Cu(+) transporter.
based on mapping to UniProt Q04656
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.

UniProtKB Entries (1)

Q04656
ATP7A_HUMAN
Homo sapiens
Copper-transporting ATPase 1

PDB Structure

PDB 2KMX
External Links
Method SOLUTION NMR
Organism
Primary Citation
The binding mode of ATP revealed by the solution structure of the N-domain of human ATP7A.
Banci, L., Bertini, I., Cantini, F., Inagaki, S., Migliardi, M., Rosato, A.
J.Biol.Chem.