CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.260 | Sortase; Chain: A; |
|
2.40.260.10 | Sortase |
Domain Context
CATH Clusters
| Superfamily | Sortase |
| Functional Family |
Enzyme Information
| 3.4.22.70 |
Sortase A.
based on mapping to UniProt Q9S446
The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.
-!- Belongs to peptidase family C60.
|
UniProtKB Entries (1)
| Q9S446 |
Q9S446_STAAU
Staphylococcus aureus
Class A sortase SrtA
|
PDB Structure
| PDB | 2KID |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
The structure of the Staphylococcus aureus sortase-substrate complex reveals how the universally conserved LPXTG sorting signal is recognized.
J.Biol.Chem.
|
