CATH Domain 2jk2B00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Triosephosphate isomerase

Enzyme Information

5.3.1.1	Triose-phosphate isomerase. based on mapping to UniProt P60174 D-glyceraldehyde 3-phosphate = glycerone phosphate.
4.2.3.3	Methylglyoxal synthase. based on mapping to UniProt P60174 Glycerone phosphate = methylglyoxal + phosphate. -!- Does not act on D-glyceraldehyde 3-phosphate. -!- Formerly EC 4.2.99.11.

UniProtKB Entries (1)

TPIS_HUMAN

Homo sapiens

Triosephosphate isomerase

PDB Structure

PDB	2JK2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Human Triosephosphate Isomerase Deficiency: Mutation E104D is Related to Alterations of a Conserved Water Network at the Dimer Interface. Rodriguez-Almazan, C., Arreola, R., Rodriguez-Larrea, D., Aguirre-Lopez, B., De Gomez-Puyou, M.T., Perez-Montfort, R., Costas, M., Gomez-Puyou, A., Torres-Larios, A. J.Biol.Chem.