CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.60 | Wheat Germ Agglutinin (Isolectin 2); domain 1 |
|
3.30.60.20 |
Domain Context
CATH Clusters
| Superfamily | 3.30.60.20 |
| Functional Family | Thymidine kinase |
Enzyme Information
| 2.7.1.21 |
Thymidine kinase.
based on mapping to UniProt O57203
ATP + thymidine = ADP + thymidine 5'-phosphate.
-!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118 and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.
|
UniProtKB Entries (1)
| O57203 |
KITH_VACCA
Vaccinia virus Ankara
Thymidine kinase
|
PDB Structure
| PDB | 2J87 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design.
Bmc Struct.Biol.
|
