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1 keywords

CATH Domain 2j0fA01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.970 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous Superfamily 1.20.970.10 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

Domain Context

CATH Clusters

Superfamily Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family Thymidine phosphorylase

Enzyme Information

2.4.2.4
Thymidine phosphorylase.
based on mapping to UniProt P19971
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P19971
TYPH_HUMAN
Homo sapiens
Thymidine phosphorylase

PDB Structure

PDB 2J0F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design.
El Omari, K., Bronckaers, A., Liekens, S., Perez-Perez, M., Balzarini, J., Stammers, D.K.
Biochem.J.
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