CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase

Enzyme Information

2.7.11.24
Mitogen-activated protein kinase.
based on mapping to UniProt P45983
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P45983
MK08_HUMAN
Homo sapiens
Mitogen-activated protein kinase 8

PDB Structure

PDB 2H96
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Zhao, H., Serby, M.D., Xin, Z., Szczepankiewicz, B.G., Liu, M., Kosogof, C., Liu, B., Nelson, L.T., Johnson, E.F., Wang, S., Pederson, T., Gum, R.J., Clampit, J.E., Haasch, D.L., Abad-Zapatero, C., Fry, E.H., Rondinone, C., Trevillyan, J.M., Sham, H.L., Liu, G.
J.Med.Chem.