CATH Domain 2g8yB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1530	Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
	1.10.1530.10	Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

Domain Context

CATH Clusters

Superfamily	1.10.1530.10
Functional Family

Enzyme Information

1.1.1.237

Hydroxyphenylpyruvate reductase.

based on mapping to UniProt P30178

(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)(+) = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H. (2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)(+) = 3-(3,4- dihydroxyphenyl)pyruvate + NAD(P)H.

-!- The enzyme participates in the biosynthesis of rosmarinic acid. -!- It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.

1.1.1.-

With NAD(+) or NADP(+) as acceptor.

based on mapping to UniProt P30178

UniProtKB Entries (1)

P30178

HCXB_ECOLI

Escherichia coli K-12

Hydroxycarboxylate dehydrogenase B

PDB Structure

PDB	2G8Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structure of a putative malate/lactate dehydrogenase from E. coli. Cuff, M.E., Skarina, T., Edwards, A., Savchenko, A., Cymborowski, M., Minor, W., Joachimiak, A. To be Published

Network disruptions