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1 keywords

CATH Domain 2fddB00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Gag-Pol polyprotein

Enzyme Information

UniProtKB Entries (1)

Q7SPG9
Q7SPG9_9HIV1
Human immunodeficiency virus 1
Pol protein

PDB Structure

PDB 2FDD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385.
Miller, J.F., Andrews, C.W., Brieger, M., Furfine, E.S., Hale, M.R., Hanlon, M.H., Hazen, R.J., Kaldor, I., McLean, E.W., Reynolds, D., Sammond, D.M., Spaltenstein, A., Tung, R., Turner, E.M., Xu, R.X., Sherrill, R.G.
Bioorg.Med.Chem.Lett.
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