CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Functional Family Ubiquitin carboxyl-terminal hydrolase

Enzyme Information
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P09936
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Homo sapiens
Ubiquitin carboxyl-terminal hydrolase isozyme L1

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Das, C., Hoang, Q.Q., Kreinbring, C.A., Luchansky, S.J., Meray, R.K., Ray, S.S., Lansbury, P.T., Ringe, D., Petsko, G.A.