CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.59 | Chorismate Mutase Domain, subunit A |
|
1.20.59.20 |
Domain Context
CATH Clusters
| Superfamily | 1.20.59.20 |
| Functional Family |
Enzyme Information
| 6.3.4.19 |
tRNA(Ile)-lysidine synthetase.
based on mapping to UniProt O67728
(tRNA(Ile2))-cytidine(34) + L-lysine + ATP = (tRNA(Ile2))-lysidine(34) + AMP + diphosphate + H(2)O.
-!- The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNA(Ile) at the oxo group in position 2 of cytidine(34). -!- This modification determines both codon and amino acid specificities of tRNA(Ile).
|
UniProtKB Entries (1)
| O67728 |
TILS_AQUAE
Aquifex aeolicus VF5
TRNA(Ile)-lysidine synthase
|
PDB Structure
| PDB | 2E89 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis of the initial binding of tRNA(Ile) lysidine synthetase TilS with ATP and L-lysine
To be Published
|
