CATH Domain 2dm6B01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.180	Quinone Oxidoreductase; Chain A, domain 1
	3.90.180.10	Medium-chain alcohol dehydrogenases, catalytic domain

Domain Context

CATH Clusters

Superfamily	Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family

Enzyme Information

1.3.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q9EQZ5
1.3.1.74	2-alkenal reductase (NAD(P)(+)). based on mapping to UniProt Q9EQZ5 A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H. -!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
1.3.1.48	15-oxoprostaglandin 13-reductase. based on mapping to UniProt Q9EQZ5 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H. -!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

UniProtKB Entries (1)

PTGR1_CAVPO

Cavia porcellus

Prostaglandin reductase 1

PDB Structure

PDB	2DM6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy Hori, T., Ishijima, J., Yokomizo, T., Ago, H., Shimizu, T., Miyano, M. J.Biochem.(Tokyo)