CATH Classification
Domain Context
CATH Clusters
| Superfamily | 1.10.1530.10 |
| Functional Family |
Enzyme Information
| 1.5.1.21 |
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH).
based on mapping to UniProt Q4U331
(1) L-pipecolate + NADP(+) = 1-piperideine-2-carboxylate + NADPH. (2) L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH.
-!- The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. -!- In contrast to EC 1.5.1.1, which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH. -!- Formerly EC 1.5.1.14.
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| 1.4.1.17 |
N-methylalanine dehydrogenase.
based on mapping to UniProt Q4U331
N-methyl-L-alanine + H(2)O + NADP(+) = pyruvate + methylamine + NADPH.
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UniProtKB Entries (1)
| Q4U331 |
PY2CR_PSEUB
Pseudomonas syringae pv. tomato
Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase
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PDB Structure
| PDB | 2CWF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction
J.Biol.Chem.
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