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1 keywords

CATH Domain 2cfyE01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.50 FAD/NAD(P)-binding domain
Homologous Superfamily 3.50.50.60 FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Thioredoxin reductase 1, cytoplasmic

Enzyme Information

1.8.1.9
Thioredoxin-disulfide reductase.
based on mapping to UniProt Q16881
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

UniProtKB Entries (1)

Q16881
TRXR1_HUMAN
Homo sapiens
Thioredoxin reductase 1, cytoplasmic

PDB Structure

PDB 2CFY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Thioredoxin Reductase 1
Debreczeni, J.E., Johansson, C., Kavanagh, K., Savitsky, P., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U.
To be Published
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