CATH Domain 2c95A00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Adenylate kinase 1

Enzyme Information

2.7.4.3	Adenylate kinase. based on mapping to UniProt P00568 ATP + AMP = 2 ADP. -!- Inorganic triphosphate can also act as donor.
2.7.4.6	Nucleoside-diphosphate kinase. based on mapping to UniProt P00568 ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. -!- Many nucleoside diphosphates can act as acceptors. -!- Many ribo- and deoxyribonucleoside triphosphates can act as donors.

UniProtKB Entries (1)

KAD1_HUMAN

Homo sapiens

Adenylate kinase isoenzyme 1

PDB Structure

PDB	2C95
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Adenylate Kinase 1 in Complex with P1, P4-Di(Adenosine)Tetraphosphate Bunkoczi, G., Filippakopoulos, P., Jansson, A., Longman, E., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Weigelt, J., Knapp, S. To be Published