CATH Classification

Domain Context

CATH Clusters

Superfamily Guanine Nucleotide Dissociation Inhibitor, domain 1
Functional Family Amine oxidase [flavin-containing]

Enzyme Information
Monoamine oxidase.
based on mapping to UniProt P27338
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC and EC, it is not inhibited by semicarbazide. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Amine oxidase [flavin-containing] B

PDB Structure

PDB 2C64
External Links
Primary Citation
Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis.
Binda, C., Hubalek, F., Li, M., Herzig, Y., Sterling, J., Edmondson, D.E., Mattevi, A.