CATH Domain 2c2xA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10860	Leucine Dehydrogenase, chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Dehydrogenase, chain A, domain 1
Functional Family	Bifunctional protein FolD

Enzyme Information

1.5.1.5	Methylenetetrahydrofolate dehydrogenase (NADP(+)). based on mapping to UniProt P9WG81 5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.
3.5.4.9	Methenyltetrahydrofolate cyclohydrolase. based on mapping to UniProt P9WG81 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.

UniProtKB Entries (1)

FOLD_MYCTU

Mycobacterium tuberculosis H37Rv

Bifunctional protein FolD

PDB Structure

PDB	2C2X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Three Dimensional Structure of Bifunctional Methylenetetrahydrofolate Dehydrogenase- Cyclohydrolase from Mycobacterium tuberculosis Javid-Majd, F., Sacchettini, J.C. To be Published