CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Amine oxidase

Enzyme Information
Primary-amine oxidase.
based on mapping to UniProt Q16853
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Membrane primary amine oxidase

PDB Structure

PDB 2C11
External Links
Primary Citation
Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1.
Jakobsson, E., Nilsson, J., Ogg, D., Kleywegt, G.J.
Acta Crystallogr. D Biol. Crystallogr.