CATH Domain 2bwpD02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family	5-aminolevulinate synthase, mitochondrial

Enzyme Information

2.3.1.37

5-aminolevulinate synthase.

based on mapping to UniProt P18079

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).

UniProtKB Entries (1)

HEM1_RHOCB

Rhodobacter capsulatus SB 1003

5-aminolevulinate synthase

PDB Structure

PDB	2BWP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of 5-Aminolevulinate Synthase, the First Enzyme of Heme Biosynthesis, and its Link to Xlsa in Humans. Astner, I., Schulze, J.O., Van Den Heuvel, J.J., Jahn, D., Schubert, W.-D., Heinz, D.W. Embo J.