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1 keywords

CATH Domain 2b17A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.90 Phospholipase A2
Homologous Superfamily 1.20.90.10 Phospholipase A2 domain

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Basic phospholipase A2 homolog

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P59071
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P59071
PA2B8_DABRR
Daboia russelii
Basic phospholipase A2 VRV-PL-VIIIa

PDB Structure

PDB 2B17
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution.
Singh, N., Jabeen, T., Sharma, S., Somvanshi, R.K., Dey, S., Srinivasan, A., Singh, T.P.
Acta Crystallogr.,Sect.D
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