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1 keywords

CATH Domain 2ar5A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1520 PX Domain
Homologous Superfamily 3.30.1520.10 Phox-like domain

Domain Context

CATH Clusters

Superfamily Phox-like domain
Functional Family Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Enzyme Information

2.7.1.154
Phosphatidylinositol-4-phosphate 3-kinase.
based on mapping to UniProt O00443
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.
-!- This enzyme also phosphorylates PtdIns to PtdIns3P.

UniProtKB Entries (1)

O00443
P3C2A_HUMAN
Homo sapiens
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

PDB Structure

PDB 2AR5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ligand-binding specificity of PI3Kinase C2alpha PX domain.
Parkinson, G.N., Vines, D., Driscoll, P.C., Djordjevic, S.
To be Published
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