CATH Domain 2ajhB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.740	Isoleucyl-tRNA Synthetase; domain 2
	3.90.740.10	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

Domain Context

CATH Clusters

Superfamily	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family	Leucine--tRNA ligase

Enzyme Information

6.1.1.4

Leucine--tRNA ligase.

based on mapping to UniProt P07813

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

SYL_ECOLI

Escherichia coli K-12

Leucine--tRNA ligase

PDB Structure

PDB	2AJH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination Liu, Y., Liao, J., Zhu, B., Wang, E.D., Ding, J. Biochem.J.