CATH Classification

Domain Context

CATH Clusters

Superfamily Receptor L-domain
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q15303
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q15303
ERBB4_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-4

PDB Structure

PDB 2AHX
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Bouyain, S., Longo, P.A., Li, S., Ferguson, K.M., Leahy, D.J.
Proc.Natl.Acad.Sci.USA