CATH Domain 2aesC00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family	beta-1,4-galactosyltransferase 1

Enzyme Information

2.4.1.90	N-acetyllactosamine synthase. based on mapping to UniProt P15291 UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. -!- The reaction is catalyzed by a component of EC 2.4.1.22, which is identical with EC 2.4.1.38, and by an enzyme from the Golgi apparatus of animal tissues. -!- Formerly EC 2.4.1.98.
2.4.1.22	Lactose synthase. based on mapping to UniProt P15291 UDP-alpha-D-galactose + D-glucose = UDP + lactose. -!- The enzyme is a complex of 2 proteins A and B. -!- In the absence of the B protein (alpha-lactalbumin) the enzyme catalyzes the transfer of galactose from UDP-galactose to N-acetylglucosamine (cf. EC 2.4.1.90).
2.4.1.-	Hexosyltransferases. based on mapping to UniProt P15291
2.4.1.38	Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase. based on mapping to UniProt P15291 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. -!- Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. -!- High activity is shown toward such residues in branched-chain polysaccharides when these are linked by beta-1,6 links to galactose residues; lower activity toward residues linked to galactose by beta- 1,3 links. -!- A component of EC 2.4.1.22.

UniProtKB Entries (1)

B4GT1_HUMAN

Homo sapiens

Beta-1,4-galactosyltransferase 1

PDB Structure

PDB	2AES
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Oligosaccharide Preferences of beta1,4-Galactosyltransferase-I: Crystal Structures of Met340His Mutant of Human beta1,4-Galactosyltransferase-I with a Pentasaccharide and Trisaccharides of the N-Glycan Moiety Ramasamy, V., Ramakrishnan, B., Boeggeman, E., Ratner, D.M., Seeberger, P.H., Qasba, P.K. J.Mol.Biol.