CATH Domain 2aeiH01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709

FA7_HUMAN

Homo sapiens

Coagulation factor VII

PDB Structure

PDB	2AEI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Cricetulus
Primary Citation	The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. Kohrt, J.T., Filipski, K.J., Cody, W.L., Cai, C., Dudley, D.A., Van Huis, C.A., Willardsen, J.A., Rapundalo, S.T., Saiya-Cork, K., Leadley, R.J., Narasimhan, L., Zhang, E., Whitlow, M., Adler, M., McLean, K., Chou, Y.L., McKnight, C., Arnaiz, D.O., Shaw, K.J., Light, D.R., Edmunds, J.J. Bioorg.Med.Chem.Lett.

Network disruptions