CATH Domain 2ae0X02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.240	Ribosomal Protein L25; Chain P
	2.40.240.50	Barwin-like endoglucanases

Domain Context

CATH Clusters

Superfamily	Barwin-like endoglucanases
Functional Family	Membrane-bound lytic murein transglycosylase A

Enzyme Information

4.2.2.n1

Peptidoglycan lytic exotransglycosylase.

based on mapping to UniProt P0A935

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0A935

MLTA_ECOLI

Escherichia coli K-12

Membrane-bound lytic murein transglycosylase A

PDB Structure

PDB	2AE0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of MltA from Escherichia coli Reveals a Unique Lytic Transglycosylase Fold van Straaten, K.E., Dijkstra, B.W., Vollmer, W., Thunnissen, A.M.W.H. J.Mol.Biol.