CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.160 | Methanol Dehydrogenase; Chain B |
|
4.10.160.10 | Methanol dehydrogenase, beta subunit |
Domain Context
CATH Clusters
| Superfamily | Methanol dehydrogenase, beta subunit |
| Functional Family |
Enzyme Information
| 1.1.2.7 |
Methanol dehydrogenase (cytochrome c).
based on mapping to UniProt P38540
A primary alcohol + 2 cytochrome c(L) = an aldehyde + 2 reduced cytochrome c(L) + 2 H(+).
-!- A periplasmic quinoprotein alcohol dehydrogenase that only occurs in methylotrophic bacteria. -!- It uses the novel specific cytochrome c(L) as acceptor. -!- Acts on a wide range of primary alcohols, including ethanol, duodecanol, chloroethanol, cinnamyl alcohol, and also formaldehyde. -!- Activity is stimulated by ammonia or methylamine. -!- It is usually assayed with phenazine methosulfate. -!- Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. -!- It differs from EC 1.1.2.8, alcohol dehydrogenase (cytochrome c), in having a high affinity for methanol and in having a second essential small subunit (no known function). -!- Formerly EC 1.1.99.8.
|
UniProtKB Entries (1)
| P38539 |
DHM1_METME
Methylophilus methylotrophus
Methanol dehydrogenase [cytochrome c] subunit 1
|
PDB Structure
| PDB | 2AD7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase
Biochem.Biophys.Res.Commun.
|
