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1 keywords

CATH Domain 2a1dA00

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.140 Epsilon-Thrombin; Chain L
Homologous Superfamily 4.10.140.10 Thrombin light chain domain

Domain Context

CATH Clusters

Superfamily Thrombin light chain domain
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P17855
STC2_STAAU
Staphylococcus aureus
Staphylocoagulase

PDB Structure

PDB 2A1D
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis for Reduced Staphylocoagulase-mediated Bovine Prothrombin Activation
Friedrich, R., Panizzi, P., Kawabata, S., Bode, W., Bock, P.E., Fuentes-Prior, P.
J.Biol.Chem.
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