CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor XI

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P05067
A4_HUMAN
Homo sapiens
Amyloid-beta precursor protein

PDB Structure

PDB 1ZJD
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2
Navaneetham, D., Jin, L., Pandey, P., Strickler, J.E., Babine, R.E., Abdel-Meguid, S.S., Walsh, P.N.
J.Biol.Chem.