CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Bifunctional polymyxin resistance protein ArnA |
Enzyme Information
| 1.1.1.305 |
UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating).
based on mapping to UniProt P77398
UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L-threo-pentapyranos-4-ulose + CO(2) + NADH.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13. -!- Formerly EC 1.1.1.n1.
|
| 2.1.2.13 |
UDP-4-amino-4-deoxy-L-arabinose formyltransferase.
based on mapping to UniProt P77398
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinose.
-!- The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305. -!- Formerly EC 2.1.2.n1.
|
UniProtKB Entries (1)
| P77398 |
ARNA_ECOLI
Escherichia coli K-12
Bifunctional polymyxin resistance protein ArnA
|
PDB Structure
| PDB | 1Z7E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance
Structure
|
