CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P50172
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P50172
DHI1_MOUSE
Mus musculus
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 1Y5R
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Murine 11-Hydroxysteroid Dehydrogenase 1: An Important Therapeutic Target for Diabetes
Zhang, J., Osslund, T.D., Plant, M.H., Clogston, C.L., Nybo, R.E., Xiong, F., Delaney, J.M., Jordan, S.
Biochemistry