CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NAD(P) transhydrogenase subunit alpha

Enzyme Information

7.1.1.1
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt Q2RSB2
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.

UniProtKB Entries (1)

Q2RSB4
PNTB_RHORT
Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit beta

PDB Structure

PDB 1XLT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Conformational Diversity in NAD(H) and Transhydrogenase Nicotinamide Nucleotide Binding Domains
Sundaresan, V., Chartron, J., Yamaguchi, M., Stout, C.D.
J.Mol.Biol.