CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information
Peptidase 1 (mite).
based on mapping to UniProt P08176
Broad endopeptidase specificity.
-!- This enzyme, derived from the house dust mite, is a major component of the allergic immune response. -!- The substrate specificity of this enzyme is not altogether clear; it cleaves the low-affinity IgE receptor CD23 at 298-Glu-|-Ser-299 and 155-Ser-|-Ser-156. -!- It also cleaves the pulmonary structural proteins occludin and claudin at Leu-|-Leu, Asp-|-Leu and at Gly-|-Thr bonds, and it can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25). -!- Using a positional scanning combinatorial library, it was found that the major substrate-specificity determinant is for Ala in the P2 position. -!- The enzyme shows only a slight preference for basic amino acids in the P1 and P3 positions and a preference for aliphatic amino acids such as Ile, Pro, Val, Leu and norleucine in the P4 position. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

Dermatophagoides pteronyssinus
Peptidase 1

PDB Structure

External Links
Organism Pichia
Primary Citation
The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen.
Meno, K., Thorsted, P.B., Ipsen, H., Kristensen, O., Larsen, J.N., Spangfort, M.D., Gajhede, M., Lund, K.