CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Protein kinase C

Enzyme Information
Protein kinase C.
based on mapping to UniProt Q04759
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Protein kinase C theta type

PDB Structure

External Links
Organism Escherichia
Primary Citation
Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)
Xu, Z.B., Chaudhary, D., Olland, S., Wolfrom, S., Czerwinski, R., Malakian, K., Lin, L., Stahl, M.L., Joseph-McCarthy, D., Benander, C., Fitz, L., Greco, R., Somers, W.S., Mosyak, L.