CATH Classification

Domain Context

CATH Clusters

Superfamily Peptide deformylase
Functional Family Peptide deformylase

Enzyme Information

3.5.1.88
Peptide deformylase.
based on mapping to UniProt P0A6K3
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

P0A6K3
DEF_ECOLI
Escherichia coli K-12
Peptide deformylase

PDB Structure

PDB 1XEO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal
Jain, R., Hao, B., Liu, R.-P., Chan, M.K.
J.Am.Chem.Soc.