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1 keywords

CATH Domain 1xa8A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.1590 glutathione-dependent formaldehyde- activating enzyme (gfa)
Homologous Superfamily 3.90.1590.10 glutathione-dependent formaldehyde- activating enzyme (gfa)

Domain Context

CATH Clusters

Superfamily glutathione-dependent formaldehyde- activating enzyme (gfa)
Functional Family

Enzyme Information

4.4.1.22
S-(hydroxymethyl)glutathione synthase.
based on mapping to UniProt Q51669
S-(hydroxymethyl)glutathione = glutathione + formaldehyde.
-!- The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, in the formaldehyde- detoxification pathway. -!- Formerly EC 1.2.1.1.

UniProtKB Entries (1)

Q51669
GFA_PARDE
Paracoccus denitrificans
Glutathione-dependent formaldehyde-activating enzyme

PDB Structure

PDB 1XA8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A dynamic zinc redox switch
Neculai, A.M., Neculai, D., Griesinger, C., Vorholt, J.A., Becker, S.
J.Biol.Chem.
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