CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1180 | Undecaprenyl pyrophosphate synthetase |
|
3.40.1180.10 | Decaprenyl diphosphate synthase-like |
Domain Context
CATH Clusters
| Superfamily | Decaprenyl diphosphate synthase-like |
| Functional Family | (2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase |
Enzyme Information
| 2.5.1.31 |
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific).
based on mapping to UniProt P60472
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.
-!- Undecaprenyl pyrophosphate synthase catalyzes the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall.
|
UniProtKB Entries (1)
| P60472 |
UPPS_ECOLI
Escherichia coli K-12
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
|
PDB Structure
| PDB | 1X06 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis.
J.Biol.Chem.
|