CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.10210
Functional Family Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Enzyme Information

2.4.2.21
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase.
based on mapping to UniProt Q7SIC7
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
-!- Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. -!- The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2. -!- It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.

UniProtKB Entries (1)

Q7SIC7
COBT_THET8
Thermus thermophilus HB8
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

PDB Structure

PDB 1WX1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of nictinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase from Thermus thermophilus HB8
Asada, Y., Kunishima, N.
To be Published