CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family

Enzyme Information

2.3.1.9
Acetyl-CoA C-acetyltransferase.
based on mapping to UniProt Q9BWD1
2 acetyl-CoA = CoA + acetoacetyl-CoA.
-!- The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. -!- The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. -!- In the second step the acyl group is transferred to an acetyl-CoA molecule. -!- Cf. EC 2.3.1.16.

UniProtKB Entries (1)

Q9BWD1
THIC_HUMAN
Homo sapiens
Acetyl-CoA acetyltransferase, cytosolic

PDB Structure

PDB 1WL5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I
Kursula, P., Sikkila, H., Fukao, T., Kondo, N., Wierenga, R.K.
J.Mol.Biol.