CATH Classification

Domain Context

CATH Clusters

Superfamily Lumazine/riboflavin synthase
Functional Family 6,7-dimethyl-8-ribityllumazine synthase

Enzyme Information

2.5.1.78
6,7-dimethyl-8-ribityllumazine synthase.
based on mapping to UniProt P9WHE9
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6- (D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H(2)O + phosphate.
-!- Involved in riboflavin biosynthesis.

UniProtKB Entries (1)

P9WHE9
RISB_MYCTU
Mycobacterium tuberculosis H37Rv
6,7-dimethyl-8-ribityllumazine synthase

PDB Structure

PDB 1W19
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,)
Morgunova, E., Meining, W., Illarionov, B., Haase, I., Jin, G., Bacher, A., Cushman, M., Fischer, M., Ladenstein, R.
Biochemistry