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1 keywords

CATH Domain 1uouA03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.1170 Aldehyde Oxidoreductase; domain 3
Homologous Superfamily 3.90.1170.30 Pyrimidine nucleoside phosphorylase-like, C-terminal domain

Domain Context

CATH Clusters

Superfamily Pyrimidine nucleoside phosphorylase-like, C-terminal domain
Functional Family Thymidine phosphorylase

Enzyme Information

2.4.2.4
Thymidine phosphorylase.
based on mapping to UniProt P19971
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P19971
TYPH_HUMAN
Homo sapiens
Thymidine phosphorylase

PDB Structure

PDB 1UOU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor
Norman, R.A., Barry, S.T., Bate, M., Breed, J., Colls, J.G., Ernill, R.J., Luke, R.W.A., Minshull, C.A., Mcalister, M.S.B., Mccall, E.J., Mcmicken, H.H.J., Paterson, D.S., Timms, D., Tucker, J.A., Pauptit, R.A.
Structure
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