CATH Classification

Domain Context

CATH Clusters

Superfamily Decaprenyl diphosphate synthase-like
Functional Family (2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase

Enzyme Information

2.5.1.31
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific).
based on mapping to UniProt P60472
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.
-!- Undecaprenyl pyrophosphate synthase catalyzes the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall.

UniProtKB Entries (1)

P60472
UPPS_ECOLI
Escherichia coli K-12
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

PDB Structure

PDB 1UEH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton
Chang, S.-Y., Ko, T.-P., Liang, P.-H., Wang, A.H.-J.
J.Biol.Chem.