CATH Classification

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD(P) transhydrogenase subunit beta

Enzyme Information
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt Q13423
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
NAD(P) transhydrogenase, mitochondrial

PDB Structure

PDB 1U31
External Links
Organism Escherichia
Primary Citation
Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase.
Mather, O.C., Singh, A., van Boxel, G.I., White, S.A., Jackson, J.B.