CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Thiazole synthase |
Enzyme Information
| 2.8.1.10 |
Thiazole synthase.
based on mapping to UniProt O31618
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur- carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)- ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O.
-!- H(2)S can provide the sulfur in vitro. -!- Part of the pathway for thiamine biosynthesis.
|
UniProtKB Entries (1)
| O31617 |
THIS_BACSU
Bacillus subtilis subsp. subtilis str. 168
Sulfur carrier protein ThiS
|
PDB Structure
| PDB | 1TYG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Thiamin Biosynthesis in Bacillus subtilis: Structure of the Thiazole Synthase/Sulfur Carrier Protein Complex
Biochemistry
|
