CATH Domain 1twfB07
|2.40.50||OB fold (Dihydrolipoamide Acetyltransferase, E2P)|
|220.127.116.11||RNA polymerase II, Rpb2 subunit, wall domain|
|Functional Family||DNA-directed RNA polymerase subunit beta|
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 18.104.22.168 and EC 22.214.171.124.
UniProtKB Entries (1)
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.