CATH Domain 1twfA09
|3.30.1360||Gyrase A; domain 2|
|Functional Family||DNA-directed RNA polymerase subunit|
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 184.108.40.206 and EC 220.127.116.11.
UniProtKB Entries (1)
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.