CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family

Enzyme Information

4.1.99.22
GTP 3',8-cyclase.
based on mapping to UniProt P65388
GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8- cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor.
-!- The enzyme catalyzes an early step in the biosynthesis of the molybdenum cofactor (MoCo). -!- The enzyme belongs to the superfamily of radical S-adenosyl-L- methionine (radical SAM) enzymes. -!- Formerly EC 4.1.99.18.

UniProtKB Entries (1)

P65388
MOAA_STAAN
Staphylococcus aureus subsp. aureus N315
GTP 3',8-cyclase

PDB Structure

PDB 1TV7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.
Hanzelmann, P., Schindelin, H.
Proc.Natl.Acad.Sci.Usa