CATH Domain 1tsvA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P00469

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_LACCA

Lactobacillus casei

Thymidylate synthase

PDB Structure

PDB	1TSV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Finer-Moore, J.S., Fauman, E.B., Morse, R.J., Santi, D.V., Stroud, R.M. Protein Eng.