CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P00469
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase

PDB Structure

PDB 1TSL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based design of inhibitors specific for bacterial thymidylate synthase.
Stout, T.J., Tondi, D., Rinaldi, M., Barlocco, D., Pecorari, P., Santi, D.V., Kuntz, I.D., Stroud, R.M., Shoichet, B.K., Costi, M.P.
Biochemistry